Theory of mind deficits in Parkinson’s disease are not modulated by dopaminergic medication

Introduction Patients with Parkinson’s disease (PD) exhibit deficits in social cognition, particularly respect to Theory of Mind (ToM) capacities. It is unclear whether they are associated PD-related dopamine deficiency and modulated by levodopa replacement therapy. Methods A total 15 persons PD 13 healthy controls (HC) participated the study. They performed different neuropsychological tasks, including Faux Pas Recognition Test (FPRT), assessing dimensions cognitive ToM (e.g., detection, inappropriateness, intentions), Reading Eyes (RMET) as an index affective ToM. Persons were tested twice, once under their regular treatment another time after at least 18 h withdrawal (MED-ON MED-OFF, respectively). On either occasion, serum drug levels motor symptom severity [Unified Disease Rating Scale (UPDRS)] measured. Results MED-ON MED-OFF conditions patients confirmed higher former than latter state a corresponding amelioration deficit. In so doing, no performance difference any ToM-related task was identified function Generally, worse both tests. Conclusion have Dopamine replacement, effective for improving condition, does not appear counteract these dysfunctions.